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Cardizem Side Effects
Cardizem Lawsuit

              Cardizem LA, a diltiazem hydrochloride extended release tablet, is used alone or with other antihypertensive medications, to treat hypertension. Cardizm LA is also used for the management of chronic stable angina.

              Cardizem LA Tablets are for oral administration and are formulated as a one-a-day extended release tablet containing 120 mg, 180mg, 240mg, 300mg, 360mg, or 420mg of diltiazem hydrochloride. The tablets are white and capsule shaped with “B” deposed on one side and the diltiazem content (mg) on the other side and should be stored at 77 °F with excursions permitted to 59-86°F. Excessive humidity an temperatures above 86°F should be avoided.

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Darvon Side Effects Lawsuit


              Darvon, propoxyphene hydrochloride capsules, is used to relieve mild to moderate pain. It is a white crystalline, odorless powder wit h a bitter tasted.  The drug is soluble freely in water and has a molecular weight of 375.94. Darvon is chemically 2S,3R)-(+)-4-(Dimethylamino)-3-methyl-1,2-diphenyl-2-butanol propionate (ester) hydrochloride.

              Darvon capsules are supplied as 65mg, opaque pink capsules with “Darvon” imprinted in edible black ink on the body. They are provided in bottles of 100. Each capsule contains 65 mg (172.9 µmol) propoxyphene hydrochloride as well as other inactive ingredients such as D & C Red No. 33, F D & C Yellow No. 6, gelatin, magnesium stearate, silicone, starch, titanium dioxide.

              The recommended dose of Darvon is 65mg,  or one capsule, every 4 hours. The recommended maximum dose of the drug is 390mg/day. Patients with hepatic or renal impairment should consider a reduced total daily dose of Daevon.

              Poison Control Center should be called to obtain the most up-to-date information about the treatment of overdose if one were to ever occur. If a propoxyphene overdose were to occur, attention should first be focused on establishing a patent airway and restoring ventilation. Ventilation assisted mechanically, with or without oxygen, may be required and if pulmonary edema is present, positive pressure respiration may be desirable. Antagonist nalxone, the narcotic, will reduce the degree of respiratory depression. 0.4mg to 2mg should be administered, preferably intravenously, promptly.

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Elidel Side Effects Lawsuit


              Elidel, a pimecrolimus cream, is used as the second-line therapy, in non- immunocompromised adults and children 2 years of age and older, for short-term and non-continuous chronic treatment of mild to moderate atopic dermatitis in patients who have failed to respond adequately to other topical prescription treatments or when other topical prescription treatments are not advisable.

              Elidel is available in a 30 gram tube, a 60 gram tube, and a 100 gram tube and the cream contains the immunosuppressant 33-epi-chloro-derivative of the macrolactam ascomycin called pimecrolimus. 10mg of pimecrolimus is contained in each gram of Elidel Cream 1%. The pimecrolimus is contained in a whitish cream base of cetyl alcohol, benzyl alcohol, citric acid, oleyl alcohol, propylene glycol, sodium cetostearyl sulphate, mono-glycerides, di-glycerides, sodium hydroxide, stearyl alcohol, triglycerides, and water. The cream should be stored at 77°F and the excursions are permitted to 59°F-86°F. The cream is not to be frozen.

              The compound pimecrolimus is a fine crystalline, white to off-white powder that is soluble in methanol and ethanol but is not soluble in water. It has a molecular weight of 810.47 and is chemically (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-12-[(1E)-2-{(1R,3R,4S)-4-chloro- 3-methoxycyclohexyl}-1-methylvinyl]-17-ethyl-1,14-dihydroxy-23,25-dimethoxy- 13,19,21,27-tetramethyl-11,28-dioxa-4-aza-tricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16- tetraone. The empirical formula for the compound is C43H68CINO11.

Elidel Side Effects Lawsuit

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Wellbutrin Side Effects Lawsuit

 

              Wellburtrin, bupropion hydrochloride Tablets, are used to treat major depressive disorder.  Supplied for oral administration, each prescription consist of either 75mg gold tablets or 100mg red, film coated tablets. The labeled amount of bupropion hydrochloride is present in each tablet as well as the following inactive ingredients:

75mg tablet

·       D&C Yellow No. 10 Lake

·       FD&C Yellow No. 6 Lake

·       Hydroxypropyl Cellulose

·       Polyethylene glycol

·       Talc

·       Titanium Dioxide

·       Hypromellose

·       Microcrystalline Cellulose

100mg Tablet

·       FD&C Red No. 40 Lake

·       FD&C Yellow No. 6 Lake

·       Hydroxypropyl Cellulose

·       Hypromellose

·       Microcrystalline Cellulose

·       Polyethylene Glycol

·       Talc

·       Titanium Dioxide

Bupropion hydrochloride produces the feeling of local anesthesia on the oral mucosa and is a powder that is crystalline, white, and soluble highly in water.

Wellbutrin, closely resembling the structure of diethylpropion, is an antidepressant that belongs to the aminoketone class and is unrelated chemically to selective serotonin re-uptake inhibitor, tricyclic, tetracyclic, and other known antidepressant agents.

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Xigris Side Effects Lawsuit


              Xigros, a drotrecogin alfa drug, is used for the intravenous treatment of sepsis. This drug is a recombinant form of human activated protein C and is supplied as preservative-free, lyophilized, sterile, white to off-white powder for intravenous infusion. The vials are 5 to 20 mg and contain 5.3mg and 20.8mg of drotrecogin alfa (activated). The vials also contain 40.3 and 158.1 mg of sodium chloride, 10.9 and 42.9 mg of sodium citrate, and 31.8 and 124.9 mg of sucrose.

              Drotrecogin alfa (activated) is a serine protease with the same amino acid sequence as human plasma-derived activated protein C and is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Human plasma-derived activated protein C and Drotrecogin alfa (activated) have the same sites of glycosylation, although some differences in the glycosylation structures exist

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