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Bextra Lawsuit Attorney


Bextra Lawsuit Attorney

Bextra Side Effects LawsuitPfizer withdrew Bextra from the U.S. market in April 2005 on the recommendation of the FDA. Introduced in November 2001, this non-steroidal anti-inflammatory drug was used to treat pain, stiffness, and inflammation associated with arthritis and other ailments. However, a number of research reports and government reviews held the drug responsible for causing rare skin reactions and increased risk of fatal cardiovascular problems in users.

Bextra Complaints

Bextra was the second Cox-2 inhibitor to be withdrawn from the market after the Vioxx recall in 2004. Some of the side effects of the drug includes increased risk of heart attack, stroke, rare skin disease called Stevens–Johnson syndrome.

In October 2004, Pfizer acknowledged the cardiovascular side effects of Bextra. A report presented to the American Heart Association also highlighted that patients using Bextra were 2.19 fold more likely to suffer heart attack or stroke. A study published by the University of Pennsylvania in November claimed that Bextra posed greater risk of heart attack and stroke than Vioxx, which was withdrawn a month before the report had been made public.

In December 2004, the FDA issued a public health advisory asking doctors to limit use of Bextra and diagnose heart patients properly before prescribing the drug. Four months later, the federal regulator ordered Pfizer to immediately stop selling Bextra, citing major heart and skin problems caused by the drug. The European Union and Canada also suspended the sale of the drug with immediate effect. In December 2005, Health Canada banned Bextra on the recommendations of an expert panel.

In March 2009, a former sales manager from Boston pleaded guilty to selling Bextra inappropriately. She had directed 100 sales representatives working under her supervision to promote the drug for reasons rejected by the FDA. About half a dozen whistleblowers followed the suit and disclosed the unlawful practices adopted by Pfizer for marketing Bextra to the federal investigators.

Bextra Side Effects

Skin Disorders

The FDA has received reports of 87 cases of severe skin reactions, including four deaths, linked to Bextra. Stevens-Johnson Syndrome, a toxic epidermal necrolysis disorder, is the most prominent side effect of the drug. Many patients found themselves affected with the syndrome within two weeks of taking the drug. This complex syndrome affects the skin and mucous membranes, leading to rashes, mucosal lesions, and cell death.

Cardiovascular Side Effects

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Ortho Evra Lawsuit


Ortho Evra Side Effects Lawsuit

Ortho Evra contraceptive skin patch by Johnson & Johnson’s subsidiary Ortho-McNeil has been popular since November 2001. The patch contains a combination of hormones that prevents ovulation in females. It also causes changes in cervical mucus, which, in turn, prevents sperms from reaching the uterus. However, Ortho Evra has serious side effects. According to an Associated Press investigation report, the hormonal contraception patch triples the risk of developing life-threatening blood clots. The serious side effects of the drug include deep vein thrombosis, strokes, pulmonary embolisms, heart attacks, and deaths.

Ortho Evra Complaints and Warnings

According to a study conducted by the FDA in 2004, Ortho Evra led to a three-fold increase in blood clot-related fatal incidents, such as pulmonary embolisms, strokes, heart attacks, and deaths. The reports, made public by the Associated Press in July 2005, claimed that there were at least 23 Ortho Evra deaths, including 17 caused by blood clots until 2004. The study was also apprehensive that the actual side effects were more widespread as the post-marketing reviews covered only 1-10 percent patch users.

The first known Ortho Evra fatality was reported in April 2004. Autopsy of an 18-year-old Manhattan fashion student revealed a blood clot in the lung. The victim was using Ortho Evra and the medical examiner blamed the side effects of the birth control patch for the young woman's death. Another woman, a 25 year-old-mother of three, died of blood clots in her brain. The medical reports held hormones released by Ortho Evra responsible for the death.

In November 2005, the FDA ordered the manufacturer to modify labels on the drug reflecting the increased risk of blood clots and other severe side effects. An advisory issued by Ortho McNeil within days warned that the patch exposed users to 60% more estrogen than pills, which could lead to serious health risks.  In March 2006, the FDA announced further review of Ortho Evra and asked label update on the package following a comparative study on the side effects of the patch and other birth control pills. According to the research, the excessive hormones in the patch do not dilute during the digestive process, unlike other pills. They are absorbed directly into the blood stream and cause higher concentration of estrogen, which puts users at a greater risk of clots, thrombosis, and heart strokes.

The consumer advocacy group Public Citizen filed a petition signed by 80,000 individuals to FDA demanding recall of Ortho Evra in May 2008. The petition mentioned cases of unreasonable blood clot and other serious health problems that the birth control patch caused within six months of taking it.

Ortho Evra Side Effects

Blood Clots:

Thromboembolic risks are the most documented side effect of Ortho Evra. The patch increases level of estrogen and progestin hormones in the blood. It releases 60 percent more estrogen compared to birth control pills, and this directly enters the patient’s blood stream, putting them at a greater risk of developing blood clots. Most of the Ortho Evra side effect victims are diagnosed with deep vein thrombosis and pulmonary embolism. Blood clots mostly develop in a deep vein in the pelvic region or legs. It breaks off and travels upward to the lungs, which can cause major artery blocks.

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Fosamax Side Effects Lawsuit


Fosamax Side Effects Lawsuit

Fosamax Side Effects LawsuitAlendronic acid or Alendronate, sold as Fosamax by Merck, was licensed in 1995 as a treatment for osteoporosis. Since 1995, more than 10 million patients have taken the drug. The bisphosphonate drug is mostly sold as a treatment for bone diseases, where there is a loss of bone mass. Fosamax is designed for the treatment of bone loss due to advanced cancer, Paget’s disease, or post-menopausal osteoporosis.

FDA Warning on Fosamax

In 2004, the Food and Drug Administration asked Merck & Co. to issue a warning about the Fosamax side effects; however, a number of patients allege the drug manufacturer never informed them that the bisphosphonate drug posed a risk of jaw necrosis. About 3,000 cases of jaw necrosis have been reported among bisphosphonate drug users, including Fosamax, since 2003. In 2010, the FDA issued another warning for Fosamax consumers that they were at the risk of thigh fracture following long-term use of the drug.

Fosamax Lawsuit

Merck faces more than 900 Lawsuit nationwide over the side effects of Fosamax. In a recent lawsuit, in 2010, a federal district judge in Manhattan refused to dismiss a Fosamax lawsuit against defendant Merck & Co Inc's. The plaintiff from Indiana, Louise Maley, had alleged that after having taken Fosamax for eight-long years, she suffered jaw damage.

Fosamax Side Effects

Though Fosamax effectively works to prevent bone loss, serious side effects have been reported as a result of the use of the drug.

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Metoclopramide Side Effects Lawsuit


Metoclopramide Side Effects Lawsuit

Metoclopramide Side Effects LawsuitMetoclopramide, generic name of Reglan, is an antiemetic medication that offers short-term relief from heart burn and vomiting caused by gastroesophageal reflux. It speeds up stomach muscle functions that help in quick digestion of food. However, metoclopramide side effects lead to drug-induced movement disorders, nervous system breakdowns, and numerous major health problems. The drug has been linked to tardive dyskinesia, a serious and irreversible movement disorder.

Metoclopramide FDA Warning

The FDA allows metoclopramide drugs only as a short-term measure – up to 12 weeks. It has notified both doctors and consumers about the serious side effects of the drug associated with the off-label use. In February 2009, the FDA issued a public health advisory alerting healthcare professionals in the United States to the possible link between metoclopramide and tardive dyskinesia. It added a black box warning to the drug informing consumers and doctors about the possible side effects due to long-term use and overdose of the drug. The new label changes were made mandatory for both metoclopramide tablets and injections. The FDA also asked the manufacturer of these drugs to make necessary arrangements to put in place a proper risk evaluation and mitigation strategy so that patients receiving their drugs would be fully informed about the risk associated with metoclopramide side effects.

Metoclopramide Side Effects

Tardive Dyskinesia

Metoclopramide can cause tardive dyskinesia, a rare and fatal movement disorder. The risk of this irreversible disorder is proportionate to the duration of the drug therapy and the total cumulative dose. The longer is the duration, the greater is the risk. This neurological disorder leads to involuntary and repetitive movements of upper limbs and the lower face. Lip smacking, pursing one’s lip, chewing, impaired finger movements, unexplained and uncontrolled grimacing, troubled respiration, and brisk eye movements are the common symptoms of this syndrome. These conditions induced

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Avandamet Side Effects Lawsuit



Avandamet Side Effects Lawsuit

Avandamet Side Effects LawsuitAvandamet, comprising rosiglitazone and metformin, is a commonly prescribed drug for Type 2 diabetes patients. Approved in 1999, Avandamet works by reducing the amount of sugar produced by the liver, thus making the body more sensitive to the naturally produced insulin. However, avandamet is often linked to heart attacks, primarily because of the presence of Avandia or rosiglitazone. Manufacturer GlaxoSmithKline faces numerous lawsuits, linking the drug to severe side effects.

FDA and Avandamet

In 2010, the Federal Drug Administration first reported the possible risk of cardiovascular events on patients using rosiglitazone and thus restricted its use, allowing only those individuals to continue using the drug who do not respond to other diabetes medications.

Earlier, in 2005, the FDA seized the current Avandamet stock, thus removing the drug from the market, after its inspection team reported violation of good manufacturing norms at a GlaxoSmithKline factory. The FDA inspection team found that some Avandamet tablets had lower than the average dose of rosiglitazone, which might have resulted in poor quality drug products, causing health complications for some patients. Following this, GlaxoSmithKline only recalled some of the affected lots of Avandamet. This prompted the FDA to interfere, which

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