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Humira Side Effect Lawsuit
Our interpretation of research done by researchers at the Dallas-based Baylor Research Institute, leads us to believe in our opinion that Humira and other popular psoriasis drugs may put patients at an increased risk of heart attacks, stroke, and consequent death. The disclosure came a few months after the FDA issued a safety alert on 14 April 2011, linking the drug to a rare type of blood cancer in children and young adults. Humira, a TNF inhibitor, carries black box warning about fatal blood cancer and fungal infections.
The FDA permitted Illinois-based Abbott Laboratories to market Humira, brand name of adalimumab, in 2003 as a medication for severe rheumatoid arthritis. The drug, the first human monoclonal antibody, has been approved for use only in cases where other anti-rheumatic drugs are found to be insufficient. In 2007, the FDA allowed Humira to be used for the treatment of severely active Crohn's disease in adults. However, a number of studies have linked the drug to serious blood disorders, fungal and virus infections, liver injury, central nervous system problems leading to demyelinating disorders, cardiac failure, and tuberculosis. It suppresses TNF, a cytokine produced by white blood cells, which renders the immune system ineffective in the fight against new infections.
Humira Complaints and FDA Warnings
In 2005, the FDA disclosed that it had identified at least nine cases of neurological disorders caused by Humira within the first two years of its introduction. Two of these complaints were related to optic neuritis, inflammation of a nerve, resulting in pain and loss of function. According to a research report published in the Journal of the American Medical Association on May 17, 2006, Humira side effects put users at the risk of developing certain types of cancers.
In September 2008, the FDA issued a public health alert informing doctors about the risk of fungal infections caused by Humira side effects. The drug neutralizes tumor necrosis factor-alpha, a protein responsible for bone, tissue, and cartilage inflammation. It leads to weakening of the immune system, which makes patients using Humira vulnerable to fungal infections.
In August 2009, the FDA added black box warning on Humira alerting consumers and healthcare experts about potential risk of lymphoma, melanoma, and other cancers in children and young adults caused by the drug. The label changes came after the FDA extensively investigated reports of adolescent and child cancer caused by the drug. It found that patients developed cancers about 30 months after Humira therapy for juvenile rheumatoid arthritis, Crohn’s disease, psoriasis, and inflammatory bowel disorder.
In April 2011, the FDA confirmed that it had received 43 reports linking side effects of Humira and TNF-blockers to Hepatosplenic T-Cell Lymphoma, a cancer of white blood cells, in children and young adults.
Humira Side Effects
Humira side effects cause serious fungal, virus, bacteria, and protozoa infections. Patients using the drug are likely to suffer from respiratory tract infections, pneumonia, bronchitis, urinary tract infections, prosthetic and postsurgical infections, digestive tract infections, and other invasive opportunistic infections. Tuberculosis is the most reported infection linked to the drug side effects. According to the post-marketing surveys, Humira users are prone to serious infections, such as septic arthritis, erysipelas, and cellulitis.
Nervous System Side Effects
Use of Humira and similar TNF blockers leads to nervous system problems, such as headache, confusion, skin sensations due to peripheral nerve damage, multiple sclerosis, and subdural hematoma or blood swelling. Rare cases of hypertrophic pachymeningitisa and demyelinating disorders caused by the drug have also been reported.
Oncologic Side Effects
A number of studies and safety reviews have linked Humira to carcinoma, lymphoma, melanoma, and other oncologic side effects. It can cause breast, skin, and uterine cancers and acute myelogenic leukemia. The FDA has received many reports of cancer of the white blood cells in young adults using the drug.
Humira musculoskeletal side effects include myasthenia, myalgia, bone disorders, muscle cramps, bone necrosis, pyogenic arthritis, back pain, joint pain, nonspontaneous fracture, and tendon disorder.
Humira consumers are likely to suffer from respiratory side effects, such as upper respiratory tract infections, asthma, bronchospasm, sinusitis, and lung disorder. The drug also leads to flu-like syndrome, difficulty in breathing, decreased lung function, pneumonia, pulmonary fibrosis, and other interstitial diseases.
Gastrointestinal Side Effects
Humira have been linked to gastrointestinal carcinoma, nausea, and abdominal pain. The post-marketing reviews documented other Humira gastrointestinal side effects, such as hepatic necrosis, gall bladder inflammation, gallstones, esophagitis, gastrointestinal hemorrhage, and gastrointestinal disorders.
Cardiovascular Side Effects
Humira side effects result in cardiovascular problems, including congestive heart failure. Using the drug for a longer period can cause hypertension, chest pain, arrhythmia, coronary artery disorder, palpitation, pericardial effusion, tachycardia, and other vascular disorders.
Other Humira Side Effects
Humira causes dermatologic side effects, such as red rash, inflammation of body tissue, and herpes zoster or eruptions along a nerve path.
Humira endocrine side effects include parathyroid disorder.
Hematologic side effects of Humira create acute blood disorders, such as agranulocytosis, granulocytopenia, hypertriglyceridemia, polycythemia, and leucopenia.
Ocular side effects of Humira include cataract.
Abbott Laboratories is facing a number of Humira Lawsuit, alleging that the failure on the part of the manufacturer to warn physicians and consumers adequately about possible side effects resulted in plaintiffs suffering from serious injuries and permanent nerve damage. In June 2011, a Tennessee resident filed a Humira lawsuit against Abbott in a Memphis court, claiming that Humira side effects caused him to suffer from histoplasmosis, a life-threatening fungal infection. The lawsuit came a month after an Illinois woman sued the Humira manufacturer for optic nerve damage and vision problems caused by drug side effects. In April 2011, another Illinois woman filed a Humira lawsuit alleging that she suffered from permanent nerve damages after using the arthritis drug for three months. A number of law firms are also working on product liability Lawsuit against Abbott covering injuries caused by Humira side effects, such as nerve damages, cancer, vision problem, infections, bone disorders, and other health problems.
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