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Actonel isrisedronate sodium tablets used for the treatment of osteoporosis.
Risedronate sodium is a white and odorless fine crystalline powder that is soluble in water and aqueous solutions. It is insoluble essentially in common organic solvents. All dose strengths include the following inactive ingredients:
The dose strength-specific ingredients are as follows:
Actonel is to be taken at least 30 minutes before the first intake of food or drink, excluding water, during the day with a full glass of water and patients should not lie down for 30 minutes after taking the medication. If it is inadequate for the patient to intake food, supplemental calcium and vitamin D should be received but if received,Actonel should be taken at a different time of day for thecalcium supplement may interfere with the absorption of the medication.
For treatment to increase bone massin men the following regimen is recommended:
For treatment ofPaget ’s disease the following regimen is recommended:
In a multinational trial ofActonel which included 3232 women, ages 38 to 85, taking 5mgActonel once daily, the incidence of serious adverse side effects was plentiful. TheGastrointestinaladverse events included abdominal pain (12.2%), diarrhea (10.8%), dyspepsia (10.8%), and gastritis (2.7%).Glossitis andduodentis have also been uncommonly reported (0.1%-1%). The Musculoskeletal side effects included back pain (28%),arthralgia (23.7%),myalgia (6.7%), and bone pain (5.3%)
Actonel and otherbisphosponates can cause upper gastrointestinal disorders includingesophagitis,dysphagia, and esophageal or gastric ulcers. Dosing instructions should be followed to reduce the risk of side effects.
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