Natrecor Lawsuit

Natrecor Side Effects

Natrecor is a purified preparation for human B-type natriuretic

peptide (hBNP) and is manufactured, using recombinant DNA technology, from E.

coil. The empirical formula for Nesiritide has is C143H244N50O42S4. It is

supplied in a single-use vial.

Netrecor is used to treat patients with acutely decompensated

congestive heart failure who have dyspnea at rest or patients who have

minimal activity. Treatment with Natrecor has reduced pulmonary capillary

wedge pressure and improved dyspnea in this sort of patients.

Netrecor is for intravenous use only and blood pressure should

be monitored closely during the administration of Netrecor. If during the

administration of Natrecor hypotension occurs, the dose is

 to be reduced or

ceased. In the occurrence of hypotension other measures should be initiated

immediately to support the blood pressure such as IV fluids and changes in

the position of the body.

Natrecor Lawsuit

Natrecor Side Effects

The dose recommended when Natrecor is used for treatment is a

single IV bolus of 2mcg/kg followed by a constant infusion of 0.01mcg/kg/min.

Natrecor should not be administered at a dose higher than what is

recommended.

Natrecor is not compatible, physically or chemically, with the

following inject able formulations:

·       Heparin

·       Insulin

·       ethacrynate sodium

·       bumetanide

·       enalaprilat

·       hydralazine

·       furosemide

The incompatible drugs should not be infused wit Natrecor through the same IV

catheter.Natrecor is not compatible with, and should not be administered in

the infusion line with the preservative sodium metabisulfite. Between the use

of Natrecor and the dugs that it is not compatible with, the catheter should

be flushed appropriately.

Natrecor binds to heparin. If the catheter is heparin coated it is possible

for the patient to be neglected of an amount of Netrecor for a period of time

because it could bind to the lining of a heparin-coated catheter.

Administration of the heprin is acceptable if infused through a separate

catheter.

Natrecor is supplied in 1.5mg, single-use vials containing the nesiritide as

sterile lyophilized powder. The vial is packaged one per carton and should be

stored below 25°C.

In case of an allergic reaction, parental administration of protein

pharmaceuticals should be attended by correct precautions.

Patients who have or are known to have low cardiac filling pressures should

avoid the use of Natrecor. It is also not recommended for patients for whom

vasodilating agents are not appropriate to use Natrecor. Such patients

include those with significant valvular stenosis, restrictive or obstructive

cardiomyopathy, constrictive pericarditis, or pericardial tamponade.

Natrecor can cause the following adverse events and side-effects:

·       Tachycardia

·       Atrial fibrillation

·       AV node conduction abnormalities

·       Catheter pain

·       Fever

·       Injection site reaction

·       Confusion

·       Paresthesia

·       Somnolence

·       Tremor

·       Increased cough

·       Hemoptysis

·       Apnea

·       Increase in creatinine

·       Sweating

·       Rash

·       Leg cramps

·       Amblyopia

·       Anemia  

·       Hypotension

·       Symptomatic Hypotension

·       Asymptomatic Hypotension

·       Ventricular Tachycardia (VT)

·       Non-sustained VT

·       Ventricular Extrasystoles

·       Angina Pectoris

·       Bradycardia

·       Headache

·       Abdominal Pain

·       Back Pain

·       Insomnia

·       Dizziness

·       Anxiety

·       Nausea/Vomiting

Natrecor Lawsuit

Natrecor Side Effects

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