- Category: Side Effects Lawsuit
Cymbalta Side Effects Lawsuit
Cymbalta Side Effects, Lawsuit
Cymbalta, an antidepressant drug manufactured by Eli Lilly, has been linked to severe psychiatric side effects, including the risk of suicidal thoughts and actions, in users. Postmarketing reports have also documented the increased risk of liver injury, cholestatic jaundice, and hepatitis in patients treated with the drug therapy. Cymbalta, brand name of duloxetine, is used as a medication for major depressive and common anxiety disorders. It also helps in the treatment of fibromyalgia, diabetic neuropathy pain, chronic lower back pain, and musculoskeletal pain, including osteoarthritis. The drug inhibits certain neurotransmitters in the brain, such as serotonin, which lead to sleep and memory disorders and cause depression.
A number of research studies have highlighted the fact that Eli Lilly’s Cymbalta does not entail more benefits compared to existing medications for stress urinary incontinence, depression, and diabetic neuropathy. The FDA has rejected Eli Lilly’s request to allow the drug for stress urinary incontinence treatment, citing a large number of side effect reports linking the drug to liver toxicity and suicides. Cymbalta discontinuation also leads to a number of withdrawal symptoms, including neurological problems, sensory disturbances, and psychiatric disorders.
Cymbalta FDA Warnings
In January 2010, the FDA warned Eli Lilly against false statements made by its representatives about the benefits of Cymbalta. The federal regulator was upset about claims made by the manufacturer about the drug’s effectiveness in direct-to-consumer print advertisements without highlighting the associated risks in the main page.
In July 2011, the FDA alerted consumers and healthcare professionals abouta possible link between Cymbalta and serotonin syndrome. Patients treated with the drug therapy are likely to suffer from serious central nervous system problems when administered monoamine oxidase inhibitors, such as methylene blue and Zyvox, to treat infections. Interactions between these drugs affect the serotonin system of the brain and lead to nervous system toxicity and death.
In September 2008, the FDA ordered for a safety revision of Cymbalta for possibly causing urinary problems in patients. In October 2007, the FDA asked Eli Lilly to end deceptive promotional campaign of Cymbalta’s antidepressant benefits. The manufacturer promoted the drug for diabetic nerve pain treatment and claimed that patients treated with the drug “experience less pain
interference with overall functioning.” According to the FDA, such claims overstated Cymbalta effectiveness and omitted serious risks associated with the drug.
In October 2005, the FDA updated the Cymbalta label and added new warnings about potential risk of serious liver injuries. The label changes informed doctors to avoid prescribing the drug to patients suffering from liver problems. The alert came after the FDA received reports of hepatitis, cholestatic jaundice, and a number of liver-related problems linked to the drug therapy.
In July 2005, the FDA added black box warning to all antidepressants, including Cymbalta, for possible risks of suicidal thoughts and behavior in adult patients. In October 2007, a warning was extended to include the potential suicidal action by young adults aged between 18 and 24. The FDA specially named Cymbalta for a large number of suicidal events linked to the drug. According to reports in the New York Times, Traci Johnson, a 19-year-old girl who volunteered for Cymbalta studies, hung herself during clinical trials as a result of withdrawal syndrome associated with the drug.
Cymbalta Side Effects
Cymbalta Gastrointestinal Side Effects
Cymbalta has been linked to a number of gastrointestinal side effects. Nausea, constipation, gastritis, and dyspepsia are the most common side effects reported to the FDA. Rare side effects of the drug include irritable bowel syndrome, blood in the stool, sore throat, colon inflammation, gastric ulcer, gingivitis, and abdominal pain.
Cymbalta Nervous System Side Effects
Cymbalta inhibits neurotransmitters and impacts the normal functioning of the brain. Its side effects and interactions with certain drugs cause CNS toxicity, loss of memory, serotonin syndrome, confusion, hyperactivity, and trouble with coordination. Patients treated with the drug experience somnolence, dizziness, restless legs syndrome, seizures, insomnia, dyskinesia, lack of attention, and paraesthesia.
Cymbalta Respiratory Side Effects
Cymbalta has been linked to respiratory side effects, such as pharyngolaryngeal pain, lung infections, and upper respiratory tract infection.
Cymbalta Dermatologic Side Effects
Cymbalta is also linked to a number of dermatologic problems in patients, including the rare Stevens-Johnson syndrome. The drug has also been linked to hives, rashes, night sweating, excessive perspiration, contact dermatitis, ecchymosis, cutaneous reactions, and photosensitivity. The FDA has also received reports of erythema, face edema, and urticaria, caused due to Cymbalta side effects.
Cymbalta Genitourinary Problems
Cymbalta side effects lead to erectile dysfunction, decreased libido, orgasm and ejaculatory problems, and gynecological bleeding. There have been reports of sexual dysfunction, including penis disorder and lack of sexual drive, in patients using the drug.
Cymbalta Psychiatric Disorders
Psychiatric side effects of Cymbalta are well documented by research studies. The drug causes nervousness, nightmare, restlessness, mood swing, manic reactions, and aggressive behavior. The FDA has issued warnings for possible suicidal action by young adults treated with Cymbalta therapy.
Cymbalta Hepatic Side Effects
The drug adversely impacts liver functioning. There have been a number of reports that link the drug to jaundice, hepatitis, and liver injury. The drug can worsen condition of patients with preexisting liver problems.
Cymbalta Cardiovascular Side Effects
Increased heart rate, blood pressure, palpitation, inflammation of a leg vein, and peripheral edema are some other side effects of Cymbalta. There have been reports that link tachycardia, supraventricular arrhythmia, and hypertensive crisis to the drug.
Other Cymbalta Side Effects
- Hematologic side effects include anemia, thrombocytopenia, and decreased white blood cell count.
- Oncologic side effects include carcinomas in females.
- Musculoskeletal side effects include muscle cramps, spasms, and myalgia.
- Renal side effects include urinary tract infection, micturition urgency, and urinary hesitation
With the discovery of serious side effects of the drug, manufacturer Eli Lilly is facing a number of Cymbalta Lawsuit across the United States. Many law firms are seeking class action status for suits filed on behalf of their clients. Patients are also encouraged to sue Eli Lilly following successful award of compensation to plaintiffs over the side effects of other antidepressant drugs, such as Paxil, Tegretol, Depakote, Neurontin, Lamictal, Lyrica, and Topamax.