Diabetes Drugs Side Effects Lawsuit

Diabetes-Drug-Side-Effects-LawsuitThe health concerns caused by onset of diabetes have led to widespread use of drugs claiming to be preventing the disease. Major pharmaceutical companies are catching on the public concern and people are using their drugs to prevent diabetes without considering the side effects. According to Wisconsin University’s Professor James Stein, the claim of preventing diabetes by a drug companies is nothing but a “sleight of hand.”

Diabetes pills, such as Avandia, Actos, and Metformin, though are considered effective to prevent the disease, their side effects often outweigh the benefits. Avandia, the commonly used drug to prevent diabetes, is banned in the major European countries and restricted in the United States after the drug manufacturers admitted that it may cause heart problems. Metformin, another generic diabetes pill, reduces the transformation to diabetes by 30%, but adds gastrointestinal diseases, a problem that causes worry to everyone. Actos, the newest anti- diabetes drug, decreases the number of diabetes cases of by 72%. The New England Journal of Medicine claims that Actos slows down a person’s progression from pre-diabetes stage to diabetes. However, the study fails to throw serious light on the potential side effects and impact of this drug on our body.

Matthew Herper of Forbes Magazine, an authority on health issues, warns ... against believing in the claim by the journal as this study is sponsored by Takeda, the manufacturer of Actos. According to him, it is linked to several side effects, such as fluid buildup, heart problems, strokes, and weight gain and. Actos, once considered to be safest anti-diabetes drug has caused three deaths compared to only one in the placebo stage.

What Are Some Major Side Effects of Popular Diabetes Drugs?

The following points focus on the scientifically proven side effects of Avandia, Actos, and Metformin diabetes pills.

Avandia Side Effects Diabetes Drug

GlaxoSmithKline’s Avandia, the most well-known type 2 diabetes drug, is subject to restricted use in the United States. The FDA issued a cardiovascular safety alert on the drug in 2007 and changed its label in 2010 outlining the minimum conditions a patient needs before taking the drug. A study reveals that the drug is responsible for 100,000 heart attacks. The manufacturer, GlaxoSmithKline, has agreed to pay $250 million to compensate 5,500 by people who have filed lawsuits for suffering heart problems in them caused by the drug. They have accused the manufacturer of distributing the drug without highlighting its side effects.
 
Most of the over 6 million people using Avandia worldwide have side effects. The most common side effects are as follows.

  • Cardiovascular problems: Studies by the FDA shows people taking Avandia has 43 percent more chances of heart attack compared to those not using it. In their case, the chance of cardiac-related death has gone up by 64 percent. It is also potential cause several cardiovascular diseases.
  • Respiratory problems: It is an important side effect caused by Avandia. It may create breathing trouble, severe chest pain, and ultimately congestive heart failure.
  • Body pain: The drug causes headaches, jaw pain, and back pain. Broken arm, hand, or foot bones in women, injury caused by strain, and swelling in legs and ankles are also attributed to it. Many people taking Avandia have experienced rapid weight gain.
  • Eye problem: Vision change is a common side effect of Avandia. Patients usually experience blurred vision. Though we tend to ignore it, such a problem can be more serious that diabetes-induced diseases.
  • Harmful conditions: Avandia is life-threatening for people with severe allergic reaction, blood clotting problem, high blood pressure and hypertension, and those regularly smoking.
  • Common diseases: The drug can cause side effects, such as breathing problems, stomach pain, disorientation, easy bruising, fatigue, increased hunger and thirst, nausea, jaundice, partly paralysis, and skin rashes.
  • Not compatible: In many cases, it is found that the drug take with other medicines, such as diaretics, gemfibrozil, rifampin, steroids, and thyroid medication can elevated risk of developing more problems.
  • Many patients using Avandia also diagnosed with anemia and edema. Anemia is greater with patients using Avandia and metformin together. Edema is higher in patients treated with Avandia plus insulin.

Actos Side Effects Diabetes Drug

The side effects of using Actos, manufactured by Takeda, include both major and minor health problems. The FDA has asked the manufacturer to surround the heart risk warnings on Actos packs by an emphasized black outline. Known as the black box warning, the strongest label change on a drug, it demonstrates serious risk of cardiovascular problems. Both the American Heart Association and the American Diabetes Association have issued guidelines on the use of the drug. Potential Actos side effects include:

  • Congestive heart failure: Diabetics with mild heart disease and kidney problems using Actos are at an increased risk congestive heart failure. The Mayo Clinic Proceedings in 2003 revealed how pioglitazone in Actos can lead to shortness of breath, feet swelling, and fluid buildup in the lungs, the symptoms of potential congestive heart failure.
  • High blood pressure: Actos can play havoc with people with high blood pressure. A study conducted by the FDA showed that the increase in doses caused a sharp rise in blood pressure.
  • Link with bladder cancer: A preliminary study by the FDA shows the link between diabetes drug Actos and increased risk of bladder cancer.
  • Common symptoms: The drug also invites upper respiratory infections, headache, sinus infections, fluctuation in blood sugar level, rapid weight gain, and blurred vision.
  • Body pain: Muscle pain, tooth problems, sore throat, itching, and swelling in the feet are also indications of side effects of Actos.
  • Behavioral changes: It may also leads to irritation, early fatigue, loss of coordination, difficulty in speaking, confusion, and seizures.
  • Other changes: Increased hunger and thirst, diuretics, , vomiting, sweating, shakiness, and dizziness are also induced by Actos.

Metformin Side Effects Diabetes Drug

Metformin is available in tablet, liquid, and two long-acting forms to treat type 2 diabetes. It decreases the sugar produced by our liver and absorbed by our body, which helps in responding to internal insulin production. The side effects of Metformin can be categorized into the following:

  • Heart problem: Like other diabetes drugs, metformin also worsens the heart problem and cause congestive heart failure. Short of breath and chest pain are its common symptoms.
  • Kidney impairment: Metformin is fatal for patients with kidney problems.
  • Infections: The drug puts patients taking it at the higher risk of upper respiratory tract infections, sinusitis, flu-like symptoms, myalgia or muscle pain, sore throat, changes in taste, and tooth and nail disorders.
  • Disorders: Metformin is associated with loss of vision caused by macular degeneration, low red blood cell counts, anemia, hypoglycemia, and renewed ovulation.
  • Digestive Problems: The drug can cause digestive problems, including diarrhea, abdominal discomfort, indigestion, gastric in the alimentary canal, abnormal stools, and lack of energy.

Case Studies Showing Side Effects of Diabetes Drugs

A 2007 case study involving 200,000 patients by the LA Times revealed several hitherto unknown side effects of diabetes drugs. It prompted the FDA to push for stronger label warnings on these drugs. The study report published on the journal Circulation: Cardiovascular Quality and Outcomes showed a heightened link between deaths caused by heart failure and regular intake of diabetes pills. A paper in the Journal of Clinical Endocrinology & Metabolism claimed that these drugs put postmenopausal women suffering from Type 2 diabetes at the increased the risk of fractures and osteoporosis.