Wellbutrin Side Effects Lawsuit

 

              Wellburtrin, bupropion hydrochloride Tablets, are used to treat major depressive disorder.  Supplied for oral administration, each prescription consist of either 75mg gold tablets or 100mg red, film coated tablets. The labeled amount of bupropion hydrochloride is present in each tablet as well as the following inactive ingredients:

75mg tablet

·       D&C Yellow No. 10 Lake

·       FD&C Yellow No. 6 Lake

·       Hydroxypropyl Cellulose

·       Polyethylene glycol

·       Talc

·       Titanium Dioxide

·       Hypromellose

·       Microcrystalline Cellulose

100mg Tablet

·       FD&C Red No. 40 Lake

·       FD&C Yellow No. 6 Lake

·       Hydroxypropyl Cellulose

·       Hypromellose

·       Microcrystalline Cellulose

·       Polyethylene Glycol

·       Talc

·       Titanium Dioxide

Bupropion hydrochloride produces the feeling of local anesthesia on the oral mucosa and is a powder that is crystalline, white, and soluble highly in water.

Wellbutrin, closely resembling the structure of diethylpropion, is an antidepressant that belongs to the aminoketone class and is unrelated chemically to selective serotonin re-uptake inhibitor, tricyclic, tetracyclic, and other known antidepressant agents.

Wellbutrin Side Effects Lawsuit

Diethylpropion’s molecular weight is 276.2. It is related to phenylethylamines and is found as as (±)-1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1propanone hydrochloride. The empirical formula for Diethylpropion’s is C13H18ClNO•HCl.

Dosage of Wellbutrin should start at 200mg, given as 100mg 2 times daily, and can be increased gradually to 300mg/day, given as 100mg 3 times daily. Dosage should not exceed 300mg/day any sooner than 3 days after beginning therapy. Doses should be administerd 3 times daily, at least 6 hours between each successive dose preferably. Dose should not ever exceed 150mg in one single dose. It is important not to administer Wellbutrin in a conduct most likely to minimize the risk of seizure but it is also important to gradually increase the dosage if motor restlessness, insomnia, and agitation, seen often during the beginning of treatment, need to be minimized.

Hospitalization following suspected overdose should be considered due to the dose-related risk of seizures with Wellbutrin. There are no specific antidotes for bupropion. Contacting a poison control center for additional information on the treatment of any overdose should be considered by the physician. Consider the possibility of multiple drug involvement when managing overdosage.

Wellbutrin should not be used in patients already being treated with ZYBAN® (bupropion hydrochloride) Sustained-Release Tablets; WELLBUTRIN SR® (bupropion hydrochloride), the sustained-release formulation; WELLBUTRIN XL® (bupropion hydrochloride), the extended-release formulation; or any other medications that contain bupropion because the occurance of seizure is dose dependent.

Wellbutrin should be stored at 15° to 25°C and should be protected from light and moisture.

Wellbutrin Side Effects Lawsuit

In 2008 despite claims of Wellbutrin lacking efficiency, the FDA backed the drug saying that the cheaper, generic version of GlaxoSmithKline PLC’s Wellbutrin XL antidepressant is safe and effective

              Some side effects and adverse events associated with Wellbutrin include:

·    Cardiac arrhythmias

·    Dizziness

·    Hypertension

·    Hypotension

·    Palpitations

·    Syncope

·    Tachycardia

·    Pruritus

·    Rash

·    Anorexia

·    Appetite increase

·    Constipation

·    Diarrhea

·    Dyspepsia

·    Nausea/vomiting

·    Weight gain

·    Weight loss

·    Impotence

·    Menstrual complaints

·    Urinary frequency

·    Urinary retention

·    Arthritis

·    Akathisia

·    Akinesia/bradykinesia

·    Coetaneous temperature

·    Dry mouth

·    Excessive sweating

·    Headache/migraine

·    Impaired sleep quality

·    Increased salivary flow

·    Insomnia

·    Muscle spasms

·    Pseudoparkinsonism

·    Sedation

·    Sensory disturbance

·    Tremor

·    Agitation

·    Anxiety

·    Confusion

·    Decreased libido

·    Delusions

·    Disturbed concentration

·    Euphoria

·    Hostility

·    Fatigue

·    Fever/chills

·    Upper respiratory complaints

·    Auditory disturbance

·    Blurred vision

·    Gustatory disturbance