Carbamazepine Side Effects Lawsuit


              Carbamazepine is known as Tegretol USP Chewable Tablets and Tagretol Extended-release Tablets. It is used against epilepsy as an anticonvulsant drug to treat partial seizures, generalized tonic-clonic seizures, and mixed seizure patterns. It is also used against Trigemina Neuealgia.

              Tegretol USP is available for oral administration as chewable tablets and as XR tablets. The chewable tablets come in tablets of 100mg and tablets of 200mg and the XR tablets are available as tablets of 100mg, 200mg, and 400mg. The suspension is available for oral administration as 100mg/5mL.

 

              Carbamazepine USP is a powder that is white to off-white. The powder is practically insoluble in water and is soluble in alcohol and in acetone. The molecular weight of Carbamazeoine is 236.27 and the inactive ingredients contained in the powder of the tablets are Colloidal silicon dioxide, D&C Red No. 30 Aluminum Lake (chewable tablets only), FD&C Red No. 40 (200-mg tablets only), flavoring (chewable tablets only), gelatin, glycerin, magnesium stearate, sodium starch glycolate (chewable tablets only), starch, stearic acid, and sucrose (chewable tablets only).The inactive ingredients contained in the suspension are Citric acid, FD&C Yellow No. 6, flavoring, Polymer, potassium sorbate, propylene glycol, purified water, sorbitol, sucrose, and xanthan gum. The inactive ingredients in the Tegretol XR tablets are cellulose compounds, dextrates, iron oxides, magnesium stearate, mannitol, polyethylene glycol, sodium lauryl sulfate, and titanium dioxide (200-mg tablets only).

The dosage recommended for adults and children over the age of 12 with epilepsy is either 200mg b.i.d. for tablets and XR tablets or 1 tablespoon q.i.d. for suspension.  The dose should be increased at weekly intervals by adding up to 200mg/day. Dosage should not ever exceed 1000mg daily in children 12-15 or 1200mg in patients older than 15.

The dosage recommended for children ages 6-12 with epilepsy is either 100mg b.i.d. for tablets or XR tablets, or ½ teaspoon q.i.d. for suspension. The dose should be increased at weekly intervals by adding 100mg/day. Dosage should not ever exceed 1000mg daily.

The dosage recommended for children younger than 6 years of age with epilepsy is 10-20mg/kg/day b.i.d. or t.i.d. as tablets, or q.i.d. as suspension. The dose can be increased weekly to obtain optimal clinical response which is usually achieved at 35mg/kg,

Tegretol can be used with other anticonvulsants or alone for treatment of epilepsy. When adding Teregtol to existing anticonvulsants, it should be gradually added.

The initial recommended dose of tegretol for the treatment of Trigeminal Neuralgia is either 100mg b.i.d. for tablets or ½ teaspoon q.i.d. for suspension, for a total of 200mg daily on the first day. The daily dose can be increased up to 200mg/day by 100mg every 12 hours.

Some adverse events associated with Tegretol carbamazepine include:

Dizziness
Drowsiness
Unsteadiness
Nausea and vomiting
Aplastic anemia
Agranulocytosis
Pancytopenia
bone marrow depression
Thrombocytopenia
Leucopenia
Leukocytosis
Eosinophilia
Acute intermittent porphyria
Toxic epidermal necrolysis (TEN)
Stevens-Johnson syndrome (SJS)
Pruritic
Erythematous rashes
Urticaria
Photosensitivity reactions
Alterations in skin pigmentation
Exfoliative dermatitis
Erythema multiforme and nodosum
Purpura
Aggravation of disseminated lupus erythematosus
Alopecia and diaphoresis
Congestive heart failure
Dema
Aggravation of hypertension
Hypotension
Syncope and collapse
Aggravation of coronary artery disease
Arrhythmias and AV block
Thrombophlebitis
Thromboembolism and adenopathy or lymphadenopathy
Jaundice
Hepatitis; very rare cases of hepatic failure
Fever
Dyspnea
Pneumonitis
Pneumonia
Urinary frequency
Acute urinary retention
Oliguria with elevated blood pressure
Azotemia
Renal failure and impotence
Albuminuria
Glycosuria
 

Carbamazepine was named by the Associated Press to be one of the drugs that has been turnig up in waterways all over the world.