Valproate Lawsuit Side Effects

              Valproate sodium is sodium salt of valproic acid designated as sodium 2-propylpentanoate and has a molecular weight of 166.2. It is a white and odorless, crystalline, deliquescent powder. Valproate sodium is an ingredient used in a drug called Depacon. The Depacon solution is available in 5mL single-dose vials for intravenous injection and each mL contains valporate sodium equal to 100mg valporic acid and .40mg of edentate disodium.

              Valproate sodium is in Depacon to assist monotherapy and adjunctive therapy in treatment of patients with complex partiel sezures that take place alone or in association with other types of seizures.

Zelnorm Lawsuit

Zelnorm, a tegaserod maleate tablet, was approved in 2002 by the FDA and is used to treat constipated women with irritable bowel syndrome. In 2004 the approval was expanded to treat chronic constipation in both men and women younger than 65. The drug is no longer available in the U.S.

              The hydrogen maleate salt contained in Zelnorm is tegaserod.  tegaserod is chemically designated as 3-(5-methoxy-1H-indol-3-ylmethylene)-N-pentylcarbazimidamide hydrogen maleate. The drug’s empirical formula is C16H23N5O.C4H4O4 and the molecular weight is 417.47.

              As the maleate salt in Zelnorm, Tegaserod is a white to off-white crystalline powder and is soluble slightly in ethanol and even less soluble in water.  1.385mg of tegaserod as the maleate salt is equivalent to 1 mg of tegaserod.

              Zelnorm is available for oral use in the 2 mg and 6 mg tablets in blister packs containing 2 mg and 6 mg tegaserod and the following inactive ingredients:

·       lactose monohydrate

·       polyethylene glycol 4000

·       Crospovidone

·       glyceryl monostearate

·       hypromellose

·       poloxamer 188

Zelnorm is also available in 6mg tablets in prescription bottles containing 6mg tegaserod and the following inactive ingredients:

·       lactose monohydrate

·       colloidal silicon dioxide

·       crospovidone

·       glyceryl behenate

·       hypromellose

Zelnorm is used to treat patients less than 65 years of age with chronic idiopathic constipation and for the treatment of women with IBS. Zelnorm’s effectiveness in patients older than 65 years has not yet been established and its efficiency for treatment of IBS with constipation or chronic idiopathic constipation has not yet been studied beyond 12 weeks.

The recommended dose of Zelnorm for patients with Chronic Idiopathic Constipation is 6mg taken orally before meals twice daily. The need for continued therapy should be assessed periodically by patients and their physicians.

Paxil Lawsuit Side Effects

              Paxil, a paoxentine hydrochloride tablets, is an antidepressant; antidepressants may increase the risk of suicidal thinking and behavior in children and young adults. The drugs also inhabit the risk of overdose and dependency.

              Paxil is used to treat Major Depressive Disorder, Obsessive Compulsive Disorder, Panic disorder, Social Anxiety disorder, Generalized Anxiety Disorder and posttraumatic Stress Disorder.

              For Major Depressive Disorder, Paxil should be administered with or without food as a single daily dose. The initial recommended dose is 20mg/day. Patients who are Non-responsive to 20mg dosage may benefit from 10mg /day up to 50mg/day maximum and changes in dose should take place at the intervals at least one week.

Aptivus Side Effects Lawsuit

              Aptivus, available as Tapranavir Capsules and Tapranavir Oral Solution, is used for the combination antiretroviral treatment of HIV-1 infected patients who are infected with HIV-1 strains resistant to more than one protease inhibitor and who have tried multiple treatments.

Aptivus belongs to the class of 4-hydroxy-5,6-dihydro-2-pyrone sulfonamides and is a protease inhibitor of HIV-1 . The drug is soft gelatin capsules containing 250mg tipranavirfor oral administration. The capsules contain the major inactive ingredients propylene glycol, dehydrated alcohol, polyoxyl 35 castor oil, mono or diglycerides of caprylic or capric acid and gelatin.